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Chemical degradation Each active ingredient retains its chemical integrity and labeled potency within speci ed limits. Physical The original physical properties, including appearance, palatability, uniformity, dissolution, and suspendability, may be affected. Microbiological Sterility or resistance to microbial growth is retained according to the speci ed requirements. Antimicrobial agents that are present retain effectiveness within the speci ed limits. Therapeutic The therapeutic effect remains unchanged. Toxicological No signi cant increase in toxicity occurs.

The book by Gill, Murray and Wright [ 121 is an excellent general reference on numerical optimization. The importance of the book for our purposes is that it discusses the necessary key notions in numerical optimization. The description of methods in this chapter shows that, with the exception of the steepest descent method, all the methods require is a routine for the numerical solution of a system of linear equations. The Newton method also requires a routine for computing eigenvalues. Both routines are standard. Additional routines are needed for the computation of the gradient vectors and relevant Jacobian and Hessian matrices. These are problem dependent and have to be supplied by the experimenter. The Fisher scoring method discussed in Section 6.5 originates from [lo]. Our description of the Levenberg-Marquardt method largely follows [23].

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where L 2p/K is the period of the grating. The optical element illustrated in Fig. 4.9 is called a surface relief grating. Since the optical element is nonabsorbing, it is called a phase element. It is also possible to produce phase elements by spatially varying the index of refraction rather than the surface relief. This approach produces a transmittance function substantially similar in functional form and diffraction properties to the surface relief grating. It is also possible to produce diffraction gratings by modulating absorption properties of a material or both phase and absorption. The transmittance of an absorption grating might be t(x, y) 1=(1 m) 1 m cos(2px=L)], where m is a constant between zero and one. For the normally incident plane U(r) A0 e jk0 z , the eld transmitted by the absorption grating is f (x, y) A0 =(1 m) 1 m cos(2px=L) . This eld

its plentiful mitochondria. Heat is produced by fatty acid oxidation, which is uncoupled i.e. does not result in ATP synthesis. This is due to uncoupling protein-1 (UCP-1), a 32-kDa protein expressed only in brown adipocytes, and which spans the inner mitochondrial membrane (Ricquier and Bouillaud, 2000) (Figure 4.17). Oxidative phosphorylation normally drives protons into the intermembrane space, generating an electrochemical gradient that pushes protons back into the mitochondrial matrix, activating ATP synthetase. In the presence of UCP-1, the proton electrochemical gradient is short-circuited by protons re-entering the matrix through this channel; the energy generated is therefore in the form of heat, rather than ATP. UCP-1 expression and protein levels increase rapidly in response to cold, the experimental administration of 3 agonist drugs, and activation of the sympathetic nervous system. BAT is densely innervated with sympathetic nerve terminals, and its thermogenic activity is regulated by the sympathetic system. Noradrenaline released from sympathetic nerve endings acts through 3-adrenoceptors to activate adenylyl cyclase, thus increasing cAMP production. This in turn activates HSL, to generate the fatty acids that are the substrate for heat production, and also increases the expression and activity of UCP-1 (Figure 4.17). BAT is a highly vascular tissue, and sympathetic activity

FIGURE 11.43 Four variations were created using the Turbulence tool, twice holding the mouse in place (top row) and twice dragging with the tool on the left and right sides of the face (bottom row).

ALTER TABLE emp MODIFY (empno NUMBER(6,0)) ALTER TABLE emp MODIFY (empno NUMBER(8,2))

Note The selection filter finds only colors and linetypes of objects that have been specifically set as such, rather than as part of a layer definition. 11 covers layers, colors, and linetypes.

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In this case, a deletion of the parent customer will cause the custid to be set to null. Your other option for the on delete clause is cascade, which if a customer is deleted will cause all of that customer s phone numbers to be deleted in the phone_bank table. If you need to remove a constraint, you would use the drop constraint statement:

+click Trash icon in Layers palette +Option+click Trash icon in Layers palette double-click effect name in Layers palette +1 through +0 +Option+S

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Following is the output that you should see upon starting the SQLTool:

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