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The Immune System Although we have discussed the indirect effects of stress on immunity via the endocrine and nervous systems, the immune system reciprocally affects the endocrine and nervous systems When the immune system is activated, a cellmediated immune response ensues to activate T cells that attack foreign cells Activated T cells also release a series of chemical mediators to stimulate more T cell, B cell, and macrophage activity Activated macrophages then release a series of chemicals called interleukins, which are also called cytokines Although there are many interleukins, for the purposes of this chapter we primarily focus on interleukin-1 (Il-1), interleukin-2 (Il-2), and interleukin-6 (Il-6) These cytokines in turn stimulate further in ammatory processes Autoimmunity occurs when the body s immune system mistakes its own tissue as foreign (ie, an antigen) and initiates an immune response to destroy it.

In the Actions toolbox, click the Objects category, click Movie, MovieClip, and Methods, and double-click the loadMovie method to add it to the Script pane. In the Object parameter box, enter the instance name of the movie clip into which the image will load in this example, myMC. If the movie clip is not a child of the same parent as the Timeline that calls the action, you must use a target path. You can use an absolute or relative path.

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This is essentially due to the combination of more advanced technology and standardisation that enable stronger propositions (mobileextension model, technology-driven model), new revenue sources like advertising (advertisingbased model) and new forms of co-operation and ef cient processes (content-delivery model) In the Wind Turns scenario there would be a fragmented marketplace of modular, easyto-combine layers and components, which implies opportunities for autonomous businesses to provide innovative applications as separate products Spending capacity is lower in this scenario, but this may be compensated by other revenue sources such as advertising Users eagerness to actively participate in the service provisioning is important here as well It is interesting to note that, although services may be targeted to smaller segments, some of the involved components (eg payment systems) will be successful only if they can reach suf cient scale; ie they need to be used by many providers and services.

In the case of RA, the immune system attacks the synovial lining of the joints Investigators have identi ed at least one mechanism by which this process occurs In some RA patients, an acute infection causes the immunoglobulin-G (IgG) antibody to mutate The immune system then mistakes this mutated antibody for an antigen and mounts an attack against it (for review, see Mageed, Borretzen, Moyes, Thompson, & Natvig, 1997) During this attack, immunoglobulin-M (IgM) antibody binds to the mutated IgG antibody, creating a bound complex commonly referred to as rheumatoid factor (RF; Mageed et al, 1997) Although RF is not found in all RA patients, there is some evidence that RF-positive and RF-negative RA patients may differ in degree of life stress For instance, Stewart, Knight, Pakmer, and Highton (1994) found that RF-negative RA patients experienced more life stress prior to onset of RA symptoms than their RF-positive counterparts..

In the Old Rules scenario, one expects packaged selling of innovative applications and services, based on new technology that mainly extends current features of applications and services The applications would be more general in nature, more secure and reliable and provisioned to larger customer segments, thereby bene ting from economies of scale Providers would be the established players operating in much the same way they are used to Businesses will adopt the enhanced mobile services if they increase productivity and support more ef cient processes New revenue sources, other than paying customers, may be required to obtain viable business models for mobile technology-enabled services, especially in the Wind Turns scenario Advertising coupled to services and sponsoring of services is well known from the xed Internet, but they provide important opportunities for supporting mobile services as well..

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